Outcomes Study
This study is a multi-center observational real-world platform which aims to integrate data from multiple sources to facilitate patient and provider engagement, shared decision making, and participation in high-priority research questions, as well as identify a core set of patient reported outcomes (PROs) that correlates with disease progression and activity
Partner: Tornatore, MedStar Georgetown; English, MS Center of Atlanta
Status: Ongoing
Truven Aging in MS Analysis
Treatment and care management, clinical outcomes and mobility impairment in people with or without MS aged ≥ 50 years: observational 6-year analysis
Partner: Freeman and Lucas, UTSW Austin
Status: Complete
Immunome Pilot
This study aims to examine the T cells, B cells, and innate immune cells of people with MS to describe age-related changes and compare them against people without MS
Partner: Bar-Or, Univ. of Pennsylvania
Status: Complete
DISCOMS Extension
This study aims to provide data on the durability of disease inactivity, and potential risks, after discontinuing DMT(s) in MS
Partner: Cutter, University of Alabama; Corboy, University of Colorado
Status: Complete
NMSS Pilots x 3
NMSS Pilot Grant 1: Cellular Senescence in Autoimmune Demyelination - This study aims to explore the role of cellular senescence in experimental autoimmune demyelination, an animal model of MS
Partner: Oksenberg, UCSF
Status: Complete
NMSS Pilot Grant 2: Determining the Effect of Circadian Rhythms in Oligodendrocyte Lineage Cell Dynamics With Age in Multiple Sclerosis: This study aims to explore the effects of circadian rhythms in oligodendrocyte lineage cell dynamics using a mouse model of MS
Partner: Gibson, Stanford University
Status: Complete
NMSS Pilot Grant 3: Association of Senescent Cells With MS progression: This study aims to explore the association between the biological age of a person with MS and their MS disease severity
Partner: Graves, UCSD
Status: Complete
MS Brain Bank Harmonization
This study aims to explore mechanisms related to the general brain atrophy seen in MS by assembling a collection of frozen neocortical samples from 6 brain banks into a single dataset with harmonized phenotypic information and a coherent set of proteomic data
Partner: De Jager, Columbia University
Status: Ongoing
